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The majority of included publications were original research articles (n = 145), followed by review articles (n = 19)

Recent studies demonstrate that curcumin significantly downregulates miR-21 (oncomiR suppression) while upregulating miR-34a/b/c by two- to four-fold in colorectal cancer cells ( p = 0.002), miR-138 ( p = 0.024), and miR-16 ( p = 0.0001) in human subjects, demonstrating systemic miRNA modulation ( Resveratrol targets the miR-200 family and miR-125b-5p for epithelialmesenchymal transition (EMT) inhibition

Unlike traditional anti-RA drugs, SI has been consumed as a traditional food in cooked and roasted form (Goyal et al., 2022), which has also drawn considerable interests from pharmacologists due to its anti-inflammatory properties (Thi Phuong Nhung et al., 2023), and its ability to regulate gut microbiota based inflammatory and immune diseases (Li et al., 2020b)

In addition, epigenetic studies have identified increased methylation in the promoter region of the glucocorticoid receptor (GR) gene, NR3C1, which may be related to altered receptor regulation and has also been associated with childhood trauma (Vangeel et al., 2015

99% purity (HPLC)

Other neurological issues that can result from mycotoxin exposure include depression, movement disorders, dementia, and imbalance