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In aged mice, it nearly doubles muscle fiber size and enhances muscle stem cell proliferation, resulting in superior muscle regeneration post-injury 1

Thymosin alpha-1 improves pregnancy outcomes in women with recurrent implantation failure undergoing IVF-ET

In addition, in research on aging-related muscle atrophy (sarcopenia), it can promote muscle cell proliferation and differentiation, reduce muscle cell apoptosis, and enhance muscle strength and endurance by activating the SIRT1 signaling pathway

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These results support development of small molecule NNMT inhibitors as therapeutics to reverse diet-induced obesity and validate NNMT as a viable target to treat obesity and related metabolic conditions