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After OGD treatment, the number of Ki-67-positive endothelial cells significantly decreased, while the intracellular expression levels of senescence markers P21, P53, and the DNA damage indicator -H2AX were markedly elevated (Figure 3B)

145 One study that followed 1,180 participants, including 547 men, for an average of 12.3 years found men with the highest DHEA-S levels (175850 mcg/dL) were 58% less likely to develop atrial fibrillation than those with the lowest levels (0.464 mcg/dL)

doi: 10.1016/j.ajps.2023.100845 47 KumbharP.ManjappaA.ShahR.JhaN

Circadian rhythm influences cellular repair cycles, immune signaling, and oxidative stress responses
doi:10.1056/NEJMra1900500 Singh D, Agusti A, Anzueto A, et al

The R package MaAsLin2 [40] was used to carry out the multivariable associations, thanks to which the eventual correlations between metagenomic data and treatment or phenotype were assessed, whilst considering the false discovery rate