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This is supported by studies in APOE4 knock-in mice showing brain hypermetabolism in the absence of neurodegeneration [97, 141]

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Winchester, MA) valve has leaflets made from porcine pericardium onto a nitinol self-expanding stent and was delivered transseptally in an 86-year old high risk patient with improvement in MR (80)

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Abovich A, Matasic DS, Cardoso R, Ndumele CE, Blumenthal RS, Blankstein R, Gulati M (2023) The AHA/ACC/HFSA 2022 heart failure guidelines: changing the focus to heart failure prevention

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