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Chen et al (119) used high levels of GSH reductase in the TME and showed that the disulfide bond (-SS-) in SSBPEI-DOX could be specifically reduced, allowing it to bind to the conventional chemotherapeutic drug DOX and induce apoptosis or necrosis of CSCs

In addition, metabolic flux analysis using D-glucose- 13 C 6 demonstrated an increase of pyruvate and a reduction in malate and citrate levels, suggesting a decreased flux toward the tricarboxylic acid cycle after bTNF- stimulation

One another limitation of this study was the sample size

Mao Z, Hu Y, Zhao Y, et al

Trends Pharmacol Sci 16: 368374

Therefore, various layers of skin cells reaction to changes in the external environment, which affects not only the condition and appearance of the skin, but also the functioning of the whole organism [15]