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However, the SA treatments resulted in even higher H 2 O 2 levels in the roots of mutants than in wild type plants after 1 and 3 h (Fig

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Moderate exercise maintains ROS at normal physiological levels, where ROS act as key signaling molecules to activate the Nrf2 pathway and upregulate the expression of endogenous antioxidants such as HO-1, SOD, and GPx (Merry and Ristow, 2016)

Studies using high-field MRI and postmortem human brain tissues further confirm that excess iron destabilizes the labile iron pool, enhances ROS production via Fenton chemistry, disrupts respiratory chain function, alters bioenergetics, and promotes protein, DNA, and lipid damage through oxidative stress (250, 251)

10.1016/j.spinee.2013.07.490 53 OichiT.TaniguchiY.OshimaY.TanakaS.SaitoT

doi:10.1371/journal.pone.0047493 Clark, D A, and R Coker
