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Vitamin E inhibits lipid peroxide production by reducing Fe 3+ in LOX-15 (Tavakol and Seifalian, 2022), but it acts less potently than Fer-1 and Lip-1

Malonyl-CoA also plays a vital role in PUFA synthesis, where dietary linoleic acid undergoes sequential desaturation and elongation reactions catalyzed by fatty acid desaturase (FADS)2, ELOVL5 and FADS1, leading to the formation of AA (C20:4, -6), which can be further elongated by ELOVL2/4 to generate AdA (C22:4, -6) (76)

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Belimumab is not approved for people with organ disease