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Phenotypic and functional analysis of macrophages and monocytes from the peritoneum of mice following multiple doses of mRNA NPs showed that the population of immunosuppressive macrophages reduced from an average of 43% in controls to 2.5% in treated mice

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The FDA has approved a number of peptides as medications, including insulin for diabetics who dont naturally produce it and human growth hormone for children with developmental disorders caused by low levels of the hormone

It reflects the pharmacokinetic reality of clearing one medication while building another to steady state

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