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Usually, a high acetylation level indicates active transcriptional activity

Assessment of gene expression profiles in peripheral occlusive arterial disease

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The feedback regulation of PGC-1 by Fundc1 deficiency was also observed in primary cardiomyocytes, and the increased mRNA levels of PGC-1, NRF1, and TFAM in CK2-deleted cells were diminished when FUNDC1 was knocked down, suggesting that mitobiogenesis and mitochondrial turnover are accelerated by FUNDC1-mediated mitophagy [236]
