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They act as modulators of the methylation status of hypoxia-responsive elements in the promoter regions

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Sci Rep 6 , 18358 (2016)

For example, 4-HNE is reported to modify membrane-associated protein, G-protein signaling 4 (RGS4) at cysteine residue during oxidative stress, thereby altering signaling events in stressed cells (46)

Assessment of the Therapeutic Potential of Melatonin for the Treatment of Osteoporosis Through a Narrative Review of Its Signaling and Preclinical and Clinical Studies