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Hemoglobin concentrations (mmol/L) of ARA 290 patients compared with placebo were 8.9 0.21 (standard error of the mean [SEM]) versus 8.6 0.26 at baseline and 8.7 0.19 versus 8.7 0.34 at the end of dosing on wk 4

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Proline biosynthesis is a vent for TGF-induced mitochondrial redox stress