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However, the mechanistic rationale for combining these agents is sound and warrants further investigation
doi: 10.3390/cancers13112716 14 JiangHYeYWangMSunXSunTChenYet al
Increases in oxygen demand can worsen myocardial ischemia in some clinical settings (e.g

These features provided the opportunity to interact precisely with biological systems, which have been exploited extensively (Zhang et al., 2012)

Inhibition of cytochrome c oxidase in turnover by nitric oxide: Mechanism and implications for control of respiration
In addition, when erastin was combined with docetaxel in the treatment of CRPC, the growth inhibitory effect of docetaxel was found to be enhanced