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303 After ligand binding, TLRs dimerize and undergo a conformational change required for recruiting downstream signaling molecules, including the adaptor molecule myeloid differentiation primary-response protein 88 (MyD88), IL-1R-associated kinases (IRAKs), TGF-activated kinase (TAK1), TAK1-binding protein 1 (TAB1), TAB2 and TNF-receptor-associated factor 6 (TRAF6)

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doi: 10.1016/j.jtemb.2019.01.002 140 CoskunAArikanTKilincMArikanDCEkerbierH

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