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Acute treatment with 9 -THC or synthetic CB1 agonists produce well-characterized signs of intoxication and anti-nociception in humans and laboratory animals through CB1 activation (Wiley and Martin, 2003)

the higher the dose used, the better was the outcome

Glucagon-like peptide-1 (GLP-1) is an endogenous incretin with very short circulating half-life of 12 minutes, produced in the enteroendocrine cells of the small intestine (Baggio et al

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466 Additionally, mitochondrial proteases cleave presequences from matrix-targeted proteins, a process crucial for correct protein folding and maturation

The procedure lasts 20 to 30 minutes and is well-tolerated by most patients