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This study showed that SREBP1a, a major isoform in immune cells, links lipid metabolism to the innate immune response by activating lipogenesis and inflammasome formation

Mutations in the human CLPP gene can cause Perrault syndrome, among others

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In the key Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron 36 mg produced mean body weight reductions of 11.2% at 72 weeks in adults with obesity, with nearly 55% of participants achieving at least 10% weight loss and 36% achieving 15% or more