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This update was just added to the above article but for those more focused on the comments I thought Id add it here too

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Fasted-state dosing eliminates dietary nicotinamide competition for NNMT binding sites, increasing effective dose by 3542% compared to post-meal administration

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In the Liverpool cohort, plasma metformin levels were also measured

Various tests of performance, multiple sleep latency, self-report, and nocturnal polysomnography have shown that DSIP exhibits this effect, also through its ability to improve REM sleep and regulate circadian and ultradian rhythms