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The American Journal of Clinical Nutrition states that, Severe glutathione deficiency is a critical mechanism underlying the oxidative stress and oxidant damage associated with human aging

No genes related to GSH plasma-membrane transport or vacuolar GSX pump were identified

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The depletion of macrophage migration inhibitory factor (MIF), a regulator of inflammatory and immune responses, increases I/R-induced AKI accompanied by necroptosis and ferroptosis

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Tobacco plants overexpressing glyoxalases 1 and 2 or both glyoxalases together showed increased tolerance to both exogenous methylglyoxal and salt (Singla-Pareek et al., 2003)