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In brief, the protocol consists of the following steps: (1) generation of flexible regions in FOXO4 FH (residues 86-104 and 186-207), the p53 TAD2 peptide, and spin labels, randomization of the flexible regions

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This can be augmented by the fact that DSIP can also reverse withdrawal symptoms, particularly from alcohol and opioids (4)

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p = 0.996), employment ( p = 0.860) and smoking habit ( p = 0.318) did not seem to influence the ProBDNF levels

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