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Observed reductions in BP after 68 weeks of CagriSema treatment versus placebo were greater than those previously observed over the same time frame for semaglutide 2.4 mg in participants with overweight or obesity in the Semaglutide Treatment Effect in People with Obesity (STEP) 1, STEP 3, and STEP 4 trials, with an overall reduction in SBP versus placebo across the 3 trials of 5.0 (95% CI, 5.9 to 4.1) mm Hg

Choi H, Schoeni RF, Martin LG, Langa K M

While subjective, this observation aligns with the peptides known mechanisms and provides a tangible indicator that something is happening at the tissue level

R.MicalizioG

However, this conformational change reduces the space available to accommodate the -helix of the peptide increasing the steric hindrance between the bulky ionic lock (R17 Cagri- E14 Cagri ) and ECL2

For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid