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10.1038/s41522-022-00303-1 Summary Keywords atherosclerosis, gut flora, flavin-containing monooxygenase-3, trimethylamine, trimethylamine N-oxide Citation Jing L, Zhang H, Xiang Q, Shen L, Guo X, Zhai C and Hu H (2022) Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis

Abbreviations ACLF: Acute-On-Chronic Liver Failure ALF: Acute liver failure ALLO: Allopregnanolone BBB: Bloodbrain barrier BCAAs: Branched-chain amino acids BDL: Bile-duct ligated cGMP: Cyclic guanosine monophosphate CFF: Critical Flicker Frequency CHE: Covert hepatic encephalopathy CHESS: Clinical Hepatic Encephalopathy Staging Scale CLF: Chronic liver failure CRT: Continuous Reaction Time CSF: Cerebrospinal fluid EEG: Electroencephalogram FMT: Fecal microbiota transplantation GPB: Glycerol phenylbutyrate HE: Hepatic encephalopathy HESA: Hepatic Encephalopathy Scoring Algorithm ICT: Inhibitory Control Test ISHEN: Society for Hepatic Encephalopathy and Nitrogen Metabolism LOLA: l-Ornithine and L-aspartate MARS: Molecular Adsorbent Recirculating System mHE: Minimal hepatic encephalopathy NKA: Na + K + ATPase OHE: Overt hepatic encephalopathy OP: Ornithine phenylacetate PEG: Polyethylene glycol PHES: Psychometric Hepatic Encephalopathy Score RBANS: Repeatable battery for the assessment of neuropsychological status RCTs: Randomized controlled trials SIRS: Systemic inflammatory response syndrome THDOC: Tetradehydrodeoxycorticosterone References American Association for the Study of Liver D, European Association for the Study of the L

The 2000 KDOQI Clinical Practice Guidelines for Nutrition in Chronic Renal Failure Work Group extensively reviewed the evidence regarding l-carnitine supplementation for diverse symptoms and complications of chronic dialysis and agreed that there was insufficient evidence to support or refute the routine use of l-carnitine for metabolic abnormalities in maintenance dialysis patients, including hypertriglyceridaemia, hypercholesterolaemia, and anaemia or for treatment for several symptoms or complications of dialysis, including intradialytic arrhythmias and hypotension, low cardiac output, interdialytic and post-dialytic symptoms of malaise or asthenia, general weakness or fatigue, skeletal muscle cramps and decreased exercise capacity or low peak oxygen consumption [8]

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