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Medically Approved

Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells

A prominent representative drug for this approach is the iron chelator DFO

The results were very similar, even though glutathione bound to GST A3-3 showed a thiol pK a value of 6.1 and Tyr9 phenol pK a of 7.9, somewhat lower than the corresponding pK a values of GST A1-1 (Johansson and Mannervik, 2002)

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