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Here, we review and discuss mechanisms of intestinal barrier loss and the role of intestinal epithelial barrier function in pathogenesis of both intestinal and systemic diseases

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The DPII-GFP Carvajal construct was created by generating a point mutation in the DPII-FL-GFP construct to match the reported mutation observed in the Carvajal patient reported in reference 31 (Epoch Life Science)

doi: 10.1038/nm.2165

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In another work, the same authors showed that SAC (300 mg/Kg) reduced the size of infarct area after 2 h occlusion and 22 h reperfusion, prevented neuronal cell death in CA1 region and inhibited the activity of ERK induced by focal ischemia in a middle cerebral artery occlusion model in gerbils, while in vitro exerted scavenging activity on peroxynitrite [28]
