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Disruptions of the TrxR1 system, although not substantially impacting either the cellular redox balance or GSH pools, disrupts embryonic patterning, Nrf2 regulation, and other signaling-dependent processes [49]
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For instance, in the reaction R + ArOH ArO + RH, a lower bond dissociation enthalpy facilitates hydrogen donation (158, 159)
When the liver efficiently clears circulating toxins and inflammatory mediators, the overall toxic burden on the immune system is reduced
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