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Cell viability analysis Cell viability was determined via the colorimetric method CellTiter 96 Aqueous (Promega Corporation, Charbonnires-Les-Bains, France), which measures mitochondrial activity according to the manufacturers instructions

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Thiamine homeostasis Thiamine is absorbed to the greatest extent by the intestinal walls, where T + it is transferred to the blood, where its target places are erythrocytes, plasma, leukocytes and platelets [36,37]

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[65] studied the effects of HA and Si substituted HA granules loaded with insulin on osteoblasts, but no obvious cell proliferation was observed