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The plasma pharmacokinetic parameters were calculated using baseline-corrected concentrations because quantifiable levels of endogenous NAC were detected at both baseline measurements (evening of Day 1 and pre-dose on Day 1)

Due to the broad-spectrum anti-microbial activity of LA, it can be used to control the balance of human gut microbiota [10]

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For those transferred to a general ward, there were two possibilities: (i) recovery and discharge or (ii) death (Figure 1)

One of the major problems with CDDP treatment is the clinical development of resistance to this drug (Perez et al, 1993)

Ionizing radiation has been reported to increase autophagy in human glioblastoma cells, thus leading to radioresistance