chac1 er stress glutathione degradation Frontiers Dysregulated lipids homeostasis disrupts CHAC1-mediated

Cisplatin, a potent antitumor agent widely employed in the chemotherapy of various solid malignancies, is notorious for severe side effects such as nausea, vomiting, cognition loss, neurotoxicity, and neuropathy

[ref] Research shows that regular acetaminophen use decreases autophagic degradation and causes lysosomal dysfunction leading to hearing loss

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This review emphasizes the importance of ferroptosis in the pathophysiology of RM and highlights its potential for guiding innovative treatments

Through these regulatory interactions, it contributes to coordinated cellular signaling within normal physiological frameworks

It is often referred to as the "master antioxidant" because it plays a central role in maintaining cellular health