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The canonical SMAD-dependent cascade is normally initiated by phosphorylation of SMAD2/3 proteins following TGF-1 receptor engagement

[DOI] [PMC free article] [PubMed] [Google Scholar] Correia-Costa L, Sousa T, Morato M, Cosme D, Afonso J, Moura C, Mota C, Areias JC, Guerra A, Schaefer F, Caldas Afonso A, Barros H, Albino-Teixeira A, Azevedo A

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Chamoun K, Kantarjian HM, Rios MB, Assi R, Garcia-Manero G, Borthakur G , Ravandi F, Jain N, Daver N, Konopleva M, DiNardo CD, Kadia TM, Pemmaraju N, Jabbour EJ, Cortes JE

These precision-engineered therapeutic modalities transcend the inherent limitations of conventional dialytic approaches in protein-bound toxin elimination, establishing a revolutionary multidimensional framework for toxin neutralization that surpasses the physical constraints of extracorporeal filtration methodologies
