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GHRP-2 also produces a modest and dose-dependent stimulation of ghrelin in peripheral tissues, which may contribute to its appetite-stimulating effects observed in research subjects and which has made it valuable for studying the ghrelin-GH axis interaction

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In addition, protein therapeutics display higher potencies (picomolar to femtomolar range) than small molecules (nanomolar range), as well as highly specific receptor binding to reduce off-target effects [5]