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Limitations and Research Status While preclinical data is extensive, large-scale human clinical trials are limited

Minimising repeated temperature fluctuations

10.1016/j.molstruc.2013.01.049 37 GaoT

Excessive plunger pressure is a warning sign

For example, endocrine experts caution that the age-related GH decline might even be protective (theres ongoing debate), and artificially raising hormone levels in someone without deficiency could do more harm than good