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Specifically, 4-HNE has been shown to induce the nuclear localization of Nrf2, a transcription factor that regulates the expression of antioxidant proteins like heme oxygenase-1 (HO-1)

fermentum A51 showed good tolerance to simulated gastrointestinal tract and possessed antioxidant and antimicrobial activities, as well as EPS synthesis capacities

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Moreover, some Chinese scholars have found that dysfunction of the mTOR signaling pathway is closely related to tumor formation, and mTOR protein is highly expressed in glioma, suggesting that abnormal mTOR signaling may be an important pathogenesis of glioma

doi: 10.1016/j.ab.2019.113559

Upon binding to its own receptor, IGF-1 signals the pituitary gland to secrete less growth hormone and, at the same time, tells the hypothalamus to secrete less GH-releasing hormone