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[Abstract]2024 May:146:107261

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Prominent features include epithelial barrier dysfunction, delayed or accelerated gastrointestinal transit due to abnormal function of smooth muscles, dysfunctional enteric nervous system and/or immunity, gut microbial dysbiosis, bile acid malabsorption, and alterations in the gut-brain axis (812)

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We do, however, find that the full-length CBS filament is more stable and less prone to thermal activation than the loop-deleted CBS 516525 dimer (Fig