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Interestingly, the tissues of the HFD-fed mice showed a significant decrease in the mRNA levels of the GSH-biosynthesis genes ( NRF2 , GCLC , and GCLM ), VD regulatory genes ( CYP2R1 , CYP27A1 , CYP27B1 , VDBP , and VDR ) in the liver, and of GSH-metabolism genes and GLUT4 gene transcription factors (VDR/PGC-1) in the skeletal muscle compared to those of mice that consumed a normal diet [44,47]

However, in terms of the cancer field, only a few of them can be employed

Adv Exp Med Biol 1999

43 Other studies have also investigated the efficacy of combination therapy of vitamin C with targeted therapies

Molecular and cellular biology

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