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Population-level data reinforce these trends

The disulfide bond creates a cyclic peptide, locking it into a bioactive conformation similar to this region of full-length hGH

The desensitization process is carried out according to a protocol that assumes a gradual increase in the drug dose until a therapeutic dose is reached, which is simultaneously associated with a gradual increase in the threshold concentration (which would cause anaphylaxis)

To review: a peptide is a short chain of amino acids that is linked by peptide (carboxyl group) bonds after a condensation reaction, removing H2O