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All groups with equal variances not assumed were evaluated by ANOVA, followed by Games-Howell multiple comparison post hoc test

These inclusions are more clearly displayed by supravital staining with methyl violet and are referred to as Heinz bodies (see Fig

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PP-1alpha mRNA and protein expression is down-regulated by leptin, which culminates in the reduction of PP-1 enzyme activity in INS-1 pancreatic -cells (Kuehnen et al., The regulation of -cell mass, (including proliferation, neogenesis, cell size, and apoptosis), is essential for the compensatory response of the endocrine pancreas to increase insulin demand, such as occurs in obesity (Marroqui et al., Thus, further studies are necessary to determine the role of leptin in the regulation of -cell mass and glucose metabolism