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CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH), modified to extend its half-life beyond the few minutes typical of native GHRH

TFEB is the major transcription factor which activates genes that encode proteins involved in autophagy, lysosome biogenesis and mitochondrial biogenesis (Settembre et al., 2011, 2012

Besides deep brain targets, surface SCAN targets on the cerebral cortex show great potential as alternatives for PD treatment

Matos IV, Castejon E, Meavilla S, OCallaghan M, Garcia-Villoria J, Lopez-Sala A, et al

Given the broad therapeutic window, the majority of stroke survivors, including those who received but were not helped by the acute interventions, would potentially benefit from such a treatment