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doi: 10.1007/s11883-017-0678-6

The four primary symptoms of Parkinsons disease are bradykinesia, rigidity, tremors, and postural instability

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DNA methylation at cytosine bases, arbitrated by the iron-dependent Ten-eleven translocases (TETs), represses gene expression by sterically hindering transcription factor binding and, via recruitment of transcriptional repressors [73,74] and iron chelation, impairs TET2 demethylation activity in in vitro adipocytes [75]

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