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Microglia expresses some pattern recognition receptors that are engaged by pathogen-associated molecular patterns, triggering microglia activation

Its most consistently documented mechanism involves VEGFR2 activation and Akt-eNOS signaling, promoting angiogenesis in connective tissue research models (Hsieh et al., Journal of Molecular Medicine, 2017, DOI: 10.1007/s00109-016-1488-y)

Sutherland ER, Crapo JD, Bowler RP

doi:10.1111/j.1469-1809.2009.00551.x

Therefore, in addition to quercetin, Phytosome technology was applied to other natural ingredients, including Berberis aristata extract, Coenzyme Q10, Melissa officinalis extract, and Curcumin [78,79,80,81]

Those are not subtle numbers they represent one of the most significant topical anti-aging results measured by objective 3D imaging in cosmetic science