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In contrast, parenteral administration, which includes intravenous, intramuscular, and subcutaneous injections, stands out because it bypasses first-pass hepatic metabolism, providing nearly complete bioavailability of the active substance

3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration

[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Lu S.C

doi: 10.1155/2020/7106525

Among enrolled participants, 10 declined participation , and 20 discontinued the intervention within the first month , primarily due to difficulties related to dietary adherence

However, The positive rate of biopsy also reached approximately 30% of healthy controls