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Mean serum concentrations of vitamin C in adults who smoke have been found to be one-third lower than those of non-smokers, and it has been recommended that smokers should consume an additional 35 mg/day of vitamin C to ensure there is sufficient ascorbic acid to repair oxidant damage [10,14]

D3 and K2 work synergistically and are best considered as a pair rather than evaluated in isolation

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The underlying mechanisms of cPT1/2 and complex I/V reduction observed in the present study is implicated to oxidative/nitrosative damage since defective mitochondria is a primary site for ROS production [30], [32]

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