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Methionine, in the form of S-adenosylmethionine (SAM), is required for many methylation reactions, including DNA methylation

doi:10.1186/s12933-014-0129-4

Transdermal forms of vitamin B 12 are available over the counter, but this route of administration has not been validated clinically in the setting of vitamin B 12 deficiency and should not be relied upon for treatment

Nurosurge Max METHYLCOBALAMIN-2500MCG INJECTION Manufacturer Strivos Pharma Pvt Ltd Nurosurge Max is a well-known brand of the methylcobalamin 2500 mcg injection that treats the vitamin B12 deficiency

Evidence Boundary Not supported by published human clinical trial data for dosing, absorption, or efficacy

They can be used as maintenance therapy to maintain energy and metabolism, or in conjunction with a formal weight loss program