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7 Apart from vegans and people with gastrointestinal conditions, infants and children from B12-deficient mothers and the elderly are at particular risk of B12 deficiency, and pregnant and breastfeeding women have higher requirements

2733, pubmed.ncbi.nlm.nih.gov/25559140/, Bruce, et al

The sixth coordination site, the center of reactivity, is variable, being a cyano group (-CN), a hydroxyl group (-OH), a methyl group (-CH3) or a 5-deoxyadenosyl group (here the C5 atom of the deoxyribose forms the covalent bond with Co), respectively, to yield the four B12 forms mentioned above

While megadoses of up to 2,000 mcg are considered safe in treating B12 deficiency, its always best to avoid excessive amounts of any vitamin, especially when its not needed

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Michael Law
