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NQO1-Nrf2-PI3K/Akt pathway The activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling has been shown to increase the expression of NQO1 in several cell types, including pheochromocytoma cells and cancer cells [100, 101]

The Trx system is also linked to changes in metabolism and the progression of metabolic disease, which could also be directly or indirectly related to ER function

Despite the numerous advantages and potential applications of NPs in animal health and nutrition, it is crucial to address safety concerns associated with their use (Reddy et al

Moreover, vitamin B12 has been reported to cause proliferation of Schwann cells and increases the diameter of axons [177]

2021 Aug 1;479(8):1691-1699
