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3 It can also result in pulmonary or systemic infection in patients who are immunosuppressed

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Epigenetic modifications, such as DNA methylation and histone acetylation, may be influenced by environmental factors like diet and physical activity, further modulating metabolic outcomes (Ray et al., 2024)

This makes injured tissue more sensitive to circulating growth factors, amplifying the repair signal without requiring additional hormone supplementation

In this field, a crucial inflammatory factor, IL-1, was observed downregulated by Lactobacillus gasseri NK109 with the simultaneous upregulated expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of mice with cognitive impairment and depression induced by Escherichia coli K1, suggesting its alleviation in brain inflammation against neuropsychiatric disorders caused by bacterial infection [86]