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Moreover, a recent study revealed that liver metastatic lesions have the lowest response rate compared with other organs in organ-level response analyses of patients with NSCLC treated with anti-PD1 therapy 33

Moreover, in TNF-related apoptosis-inducing ligand (TRAIL)-resistant HCC cells butein augmented TRAIL-induced apoptosis probably due to increased DR5 expression [97]

Toxic lipid ROS are produced by PUFA-containing phospholipids (PUFA-PLs), which are found in the membrane of the whole cell