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2001 61(9):3599 - 3603 Subcommittee on the Tenth Edition of the Recommended Dietary Allowances, Food and Nutrition Board, Commission on Life Sciences, National Research Council

PMID: 19017728

Even if lipophagy has a minor role in normal dietary conditions, it might be important in limiting lipid accumulation during transient dietary lipid overload

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This, along with a potential increase in apnoeic threshold brought on by hypoxia (which lowers the CO2 reserve even more), predisposes to central apnoea at the onset of sleep and subsequent ventilatory instability, which manifests as a hyperventilation and apnoea cycle (Hernandez & Patil, 2016)

The cellular and molecular functions of these cells cannot be assumed to be identical between juveniles and adults, and hence it is conceivable that the pathophysiological mechanisms contributing to pediatric CIPN differ from those in adults