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Some research models note mild observations including gastrointestinal effects in certain experimental protocols

Table 2 summarises some of the available preparations

This extrapolation involves two critical decisions: (1) selecting a point of departure (POD), which corresponds to the lowest dose associated with observable adverse effects within the range of data from a study, and (2) selecting the mathematical model used to extrapolate risk from typical human exposures that are well below the POD

Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude shear stress

This process is known as titration

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