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In the subcohort of 351 workers, there was a significant increase in mortality rate due to kidney disease (3 against 0.4 expected)

doi: 10.1186/s12964-021-00730-1

pathology 93 (1), 129134

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Some protocols split the daily dose into morning and evening injections for more consistent tissue levels, taking advantage of the peptide's short half-life by maintaining more frequent, lower doses

Heparanase is essential for the development of acute experimental glomerulonephritis