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Among all these, vitamin B12 is seen as a commonly deficient nutrient

doi: 10.1038/s41380-022-01456-3 173 MckernanD

358 In AD model, an increase of Tau and A protein precursor inhibited Parkin translocation to mitochondria, thus Parkin was unable to label impaired mitochondria, and mitophagy was damaged

On average, according to the Parental Global Impressions, there was little change (slight improvement) in tantrum behavior, and slight worsening of sleep and hyperactivity, so those are symptoms that should be documented in future treatment studies and may indicate possible temporary side-effects due to DMSA

This combined approach results in increased cytotoxicity, offering hope for more effective treatments