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J Clin Invest 113: 17741783, 2004

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Patients with sleep disorders frequently experience activation of the tryptophan degradation pathway that increases the turnover of tryptophan leading to a reduced level of production of serotonin for a given tryptophan blood level
Smits P, Saada A, Wortmann SB, Heister AJ, Brink M, Pfundt R, et al

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