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Moreover, the upregulation of APX activity under nanoparticle treatment may have further facilitated the effective utilization of AsA in reducing ROS, thereby linking non-enzymatic antioxidants with the enzymatic defense system

Pharmacokinetic investigations revealed that GSH at a loading dose of 1.69 g/kg and a maintenance dosage of 5.70 g/hr/kg are needed to reach 1 mM GSH which is a minimum requirement of extracellular concentration to suppress significantly the intracellular ROS

doi: 10.1001/jama.2017.17426

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